Q: What scientific research and published information support MitoBoost’s effectiveness?

A: Here is just some of the information available on MitoBoost:  

The “fountain of youth” might be found in a person’s mitochondria.

The Massachusetts Institute of Technology Review asks if the fountain of youth could be found in a person’s mitochondria. In this September 21, 2007 article they say: “A growing body of evidence suggests that mitochondrial function plays a vital role in aging and age-related ailments like Alzheimer’s, Parkinson’s heart ailments and type 2 diabetes. Researchers found that as long as the cells’ mitochondria were healthy the cells could stay alive.”

Harvard Medical School genetics professor Dr. David Sinclair has found that an NAD+ booster in animal studies can dramatically reverse the signs of aging.

In 2013, Sinclair and colleagues published a revolutionary paper  in the journal Cell.

Their study showed that giving older mice an NAD+ booster for one week made the mitochondria of 2-year-old mice resemble those of 6-month-old mice. They compared critical biochemical markers measuring muscle health.

In human terms, that would be similar to a 60-year-old’s mitochondria becoming like mitochondria of someone who is 20-year-old.

The findings were published in the Dec. 19, 2013, issue of Cell. You can read the findings here: http://www.cell.com/abstract/S0092-8674%2813%2901521-3.

A news release about the study on the Harvard Medical School website explains the significance of the findings. It says: “Mitochondria, organelles on the right, interact with the cell's nucleus to ensure a healthy, functioning cell.

The essence of this finding is a series of molecular events that enable communication inside cells between the nucleus and mitochondria. As communication breaks down, aging accelerates. By administering a molecule naturally produced by the human body, scientists restored the communication network in older mice. Subsequent tissue samples showed key biological hallmarks that were comparable to those of much younger animals.

‘The aging process we discovered is like a married couple—when they are young, they communicate well, but over time, living in close quarters for many years, communication breaks down,’ said Harvard Medical School Professor of Genetics David Sinclair, senior author on the study. ‘And just like with a couple, restoring communication solved the problem.’

This study was a joint project between Harvard Medical School, the National Institute on Aging, and the University of New South Wales, Sydney, Australia, where Sinclair also holds a position.”

MitoBoost’s  NIAGEN™ has dramatic effects on longevity and metabolism

 

Nicotinamide riboside is an important compound that promotes longevity in multiple ways. Recent lab studies show that it dramatically can affect both longevity and metabolism.  Here are some of the places in which the stunning positive effects of NR have been documented:

  • Researchers in Switzerland reported in the June 2012 issue of the journal Cell Metabolism that high doses of NR prevented obesity in mice that were fed a fatty diet. The same study also found that higher levels of NAD+ increased muscle performance, improved energy expenditure and prevented diabetes development, all without side effects.

You can read the full text of the article here: http://www.cell.com/cell-metabolism/fulltext/S1550-4131(12)00192-1.

  • A study reported on in the journal Neurobiology of Aging reported that dietary treatment with NR might benefit the cognitive function of patients suffering with Alzheimer's Disease, and that as a supplement, NR may help reduce the presence of certain Alzheimer's-associated toxins in the brain. The study identified NAD+ as a key regulator of the lifespan-extending effects. You can read the abstract of this June 2013 article here: http://www.neurobiologyofaging.org/article/S0197-4580(12)00620-3/abstract.

 

  • A study published in 2012 in the peer-reviewed, open-access journal PLoS Biology postulated that increasing NAD+ reduced the muscular degradation suffered by zebrafish with Muscular Dystrophy in zebrafish.

 

The authors noted that the results “may have future therapeutic relevance for a broad spectrum of muscular dystrophies."

You can access the study here online at http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001409.

  • A study published in 2009 in the journal Current Pharmaceutical Design by researchers from the University of Cincinnati and the University of Utah School of Medicine reported that NAD+ therapy may help in the treatment of Multiple Sclerosis. In the article, authors say NR, particularly, has “potentially great clinical therapeutic significance.” It is “the only NAD+ precursor capable of providing NAD+ directly to neurons."

Dr. Sinclair of Harvard had previously studied the effects of resveratrol  (contained in MitoBoost) on aging. Resveratrol has many known health benefits, including acutely and significantly increasing the dilation of the brachial artery. This allows the blood to better deliver oxygen and nutrients to the body.  

Previous studies from Dr. Sinclair ‘s lab showed that a “longevity gene,” SIRT1, was activated by the compound resveratrol, which is found in grapes, red wine and certain nuts.

Resveratrol is believed to be one of the forces of “the French Paradox,” the apparent contradiction wherein French people ate high fat diets but had good heart health and low cardiovascular mortality rates when compared to other Western cultures.

The first published human study to link resveratrol to the “French Paradox” was conducted by Dr. Peter Howe at the University of South Australia. The study demonstrates that resveratrol is effective in improving flow mediated dilation (FMD) in humans. FMD is a direct marker of nitric oxide bioavailability, and is linked to the healthy functioning of the cardiovascular system.

In the double-blind, placebo-controlled trial, subjects took three different doses of resveratrol (30, 90 and 270 mg). All doses were well absorbed into the blood stream in a dose-dependent manner. The reactivity of blood vessels was then measured in the brachial artery. All three doses of resVida® acutely and significantly increased the dilation of the brachial artery. The diameter of the artery was increased by 62 percent in the group who took just 30 mg of resveratrol.

Resveratrol helps reduce inflammation, prevents the oxidation of LDL “bad” cholesterol, and makes it more difficult for platelets to stick together and form the clots that can lead to a heart attack. Along with promoting cardiovascular health and healthy lipid levels, resveratrol also supports the immune system and has anti-aging and longevity benefits.

You can read a press release about Dr. Peter Howe’s resveratrol study here: http://www.dsm.com/corporate/media/informationcenter-news/2010/09/2010-09-06-dsms-resvida-improves-cardiovascular-health.html.

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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