1. What scientific research and published information support N-O Blood Boost’s effectiveness?

A: Here is just some of the information available on N-O Blood Boost:  

Levels of N-O in the body decline as people age.* 

  • Italian researchers discovered blood flow starts to decline — starting around the age of 30 with greater than 50% loss of endothelial function in those 60 years of age and older.
  • Japanese researchers reported that 70- to 80-year-olds experienced a 75-percent loss in endothelium-derived nitric oxide compared to young, healthy 20 year olds. The endothelium is where N-O is produced, so a decline in endothelial production means a decline in N-O production.

L-Citrulline is more potent at raising plasma L-Arginine levels than orally ingested arginine.*

A double-blind, randomized, placebo-controlled cross-over study of healthy adults showed that L-Citrulline was more potent at raising plasma L-Arginine levels than L-Arginine itself.

The study was published in the British Journal of Clinical Pharmacology. You can read about it here:


Adding L-Glutathione to L-Citrulline makes it a more effective N-O booster.*

Researchers at Baylor University report in the Journal of the International Society of Sports Nutrition that adding L-Glutathione makes L-Citrulline a more effective N-O booster.

A double-blind study led by Darryn Willoughby and published in the Journal of the International Society of Sports Nutrition investigated the effects of Setria Glutathione and L-Citrulline on 60 healthy, resistance-trained males aged 18-30. The men were randomly divided into four groups and received one of the following daily for a week:

  • a placebo,
  • 1 gram Setria Glutathione,
  • 2 grams L-Citrulline, or
  • 200 mg Setria Glutathione + 2 grams L-Citrulline

At the end of the seven-day period, the men performed resistance exercise sessions involving the elbow flexors and their blood was collected to assess N-O levels.

The researchers found that the combination of Setria Glutathione and L-Citrulline did, in fact, increase N-O levels in the blood to a significantly greater degree than the placebo. What’s more, at 30 minutes after the exercise, the Setria Glutathione/L-Citrulline group was the only group to present such a striking improvement over the control group.

Part of the mechanism responsible for the synergy between citrulline and glutathione is that glutathione probably speeds up the release of N-O from arginine.

Moreover, the combination of L-Citrulline and glutathione boosted the concentration of nitrite in the subjects after they'd done the workout. Nitrite is also a precursor of N-O. How exactly the combination of L-Citrulline and glutathione results in more nitrite being activated the researchers are not sure.

“In this study, we were able to determine that combining Setria Glutathione with L-Citrulline not only increased blood levels of nitrite and NOx, but sustained the increases for a longer period of time, compared to placebo,” said Willoughby. “The results of this first-of-its kind study indicate that Setria Glutathione and L-Citrulline may play a role in muscle protein synthesis and muscle performance when combined with resistance exercise.”

 You can find the study here: http://jissn.biomedcentral.com/articles/10.1186/s12970-015-0086-7.


Resveratrol can acutely and significantly increase the dilation of the brachial artery*

Resveratrol is believed to be one of the forces of “the French Paradox,” the apparent contradiction wherein French people ate high fat diets but had good heart health and low cardiovascular mortality rates when compared to other Western cultures.

The first published human study to link resveratrol to the “French Paradox” was conducted by Dr. Peter Howe at the University of South Australia. The study demonstrates that resveratrol is effective in improving flow mediated dilation (FMD) in humans. FMD is a direct marker of  endothelial function and cardiovascular health.

In the double-blind, placebo-controlled trial, subjects took three different doses of resveratrol (30, 90 and 270 mg). All doses were well absorbed into the blood stream in a dose-dependent manner. The reactivity of blood vessels was then measured in the brachial artery. All three doses of resVida® acutely and significantly increased the dilation of the brachial artery. The diameter of the artery was increased by 62 percent in the group who took just 30 mg of resveratrol.

Resveratrol helps reduce inflammation, prevents the oxidation of LDL “bad” cholesterol, and makes it more difficult for platelets to stick together and form the clots that can lead to a heart attack. Along with promoting cardiovascular health and healthy lipid levels, resveratrol also supports the immune system and has anti-aging and longevity benefits.*

You can read a press release about Dr. Peter Howe’s resveratrol study here: http://www.dsm.com/corporate/media/informationcenter-news/2010/09/2010-09-06-dsms-resvida-improves-cardiovascular-health.html.

*Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Nordic Clinical is not affiliated, associated, authorized, endorsed by, or in any way officially connected with the University of South Australia, Baylor University, the British Journal of Clinical Pharmacology, the Journal of the International Society of Sports Nutrition, the Journal of the International Society of Sports or any of its subsidiaries or its affiliates.

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